Table 1. Pharmacokinetic parameters of phrGFP siRNA following IV administration of HSA-LNPs-siRNA to ICR mice at a dose of 1 mg/kg.
Group | siRNA alone | HSA-LNPs-siRNA |
---|---|---|
AUC (μg·minr/ml) | 84.6±18.7 | 341.5±29.5 |
t½(α) (min) | 11.5±4.0 | 5.8±0.5 |
t½(β) (min) | - | 150.8±25.7 |
CL (ml/min/kg) | 11.8±2.6 | 2.9±0.2 |
MRT (0-24min) | 16.6±5.8 | 192.8±28.5 |
Data represents the mean±SD (n=3).