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. Author manuscript; available in PMC: 2013 Mar 22.
Published in final edited form as: J Musculoskelet Neuronal Interact. 2010 Mar;10(1):35–45.

Figure 9.

Figure 9

Gradations in biologic factors may promote gradations in cell differentiation and subsequent tissue formation. The measured gradations in mineral at the mature enthesis (shown in green, highest in bone and lowest in tendon) may be due to a graded expression of osteogenic factors such Runx2 and BMP-2. The measured gradations in fibrocartilage (shown in red, low in both tendon and bone and highest at the insertion) may be due to a graded expression of factors such as PTHrP, Ihh, and Sox9. Differences in tenogenesis (shown in blue, highest in tendon and lowest in bone) may be due a graded expression of tendon specific factors such as scleraxis, BMP-12, and tenomodulin.