Table 1.
Non-synonymous homoplasic SNPs identified in the core genomes of C. difficile 027/BI/NAP1 isolates. The positions refer to those in the R20291 genome. The alleles listed relate to the forward strand.
| Position | Region | SNP | Substitution | Antibiotic |
|---|---|---|---|---|
| 5420 | DNA gyrase subunit B (gyrB) |
1276G> A |
Asp426Asn | Fluoroquinolone |
| 6310 | DNA gyrase subunit A (gyrA) |
245C>T | Thr82Ile | Fluoroquinolone |
| 95412 | DNA-directed RNA polymerase beta chain (rpoB) |
1504C> A |
His502Asn | Rifampicin |
| 95422 | rpoB | 1514G> A |
Arg505Lys | Rifampicin |
| 103867 | translation elongation factor G (fusA) |
1363C> A/1363 C>T |
His455Asn/His 455Tyr |
Fusidic acid |
| 104117 | fusA | 1613C> T |
Pro538Leu | Fusidic acid |
| 1800920 | two-component response regulator |
31G>A | Glu11Lys | |
| 1802086 | two-component sensor histidine kinase |
446C>T | Thr149Ile | |
| 3170481 | S-layer precursor protein (slpA) |
467G>A /467G> T |
Pro156Leu/Pr o156Gln |
|
| 3170482 | slpA | 466G>A /466G> T |
Pro156Ser/Pro 156Thr |
|
| 3938789 | putative membrane protein |
996A>C | Tyr332* |