Table 2.
BMD, QUS and sex hormone biochemistry parameters in relation to the distribution of the UGT2B17 CNV genotype
| 0 copy | 1 copy | 2 copies | P value | |
|---|---|---|---|---|
| Hip DXA bone density (n) | (120) | (513) | (470) | |
| Total hip BMD (mg/cm2) | 0.818 ± 0.119 | 0.815 ± 0.127 | 0.806 ± 0.122 | 0.100 |
| Femoral neck BMD (mg/cm2) | 0.693 ± 0.107 | 0.690 ± 0.106 | 0.692 ± 0.100 | 0.879 |
| Heel quantitative ultrasound (n) | (154) | (591) | (551) | |
| Average BUA (Db/MHz) | 99.9 ± 7.6 | 100.9 ± 7.8 | 100.3 ± 8.2 | 0.044 |
| Average SOS (m/s) | 1512.3 ± 24.5 | 1514.8 ± 26.2 | 1510.9 ± 26.0 | 0.018 |
| Average Stiffness (%) | 70.3 ± 10.6 | 71.4 ± 11.5 | 69.9 ± 11.8 | 0.023 |
| Sex hormone biochemistry parameters (n) | (161) | (599) | (568) | |
| Estradiol (pmol/L) | 28.1 ± 16.8 | 27.8 ± 15.9 | 28.1 ± 20.8 | 0.974 |
| SHBG (nmol/L) | 52.2 ± 21.7 | 54.2 ± 26.1 | 56.8 ± 25.4 | 0.024 |
| FEI (units) | 2.73 ± 2.26 | 2.91 ± 3.14 | 3.03 ± 3.06 | 0.333 |
| Incident osteoporotic confirmed fractures | ||||
| Number (%) | 44 (27.3) | 118 (19.2) | 121 (21.1) | |
| Hazard ratio (95% CI) | 1.30 (0.92-1.83) | 0.89 (0.69-1.15) | 1 (reference) | 0.110 |
Results are given as mean±SD. P values were determined using ANCOVA. The hazard ratio for fracture was adjusted for age, height, weight, and calcium supplementation