Table 2.
Circulating L ascorbic acid by allelic variation at SCL23A1 in the British Women’s Heart and Health Study.
| Genotype at rs33972313 (n=3252) | |||||
|---|---|---|---|---|---|
| L ascorbic acid μmol/L |
GG | GA | AA | Per allele effect | p |
| 43.77 (42.80, 44.74) |
38.63 (34.90, 42.37) |
52.61 (30.16, 75.06) |
−4.15 (−7.81, −0.49) |
0.03 | |
| Genotype at rs10063949 (n=3365) | |||||
| L ascorbic acid μmol/L |
AA | AG | GG | Per allele effect | p |
| 42.54 (41.15, 43.93) |
43.85 (42.40, 45.30) |
47.01 (44.07, 49.96) |
1.91 (0.47, 3.34) |
0.009 | |
| Genotype at rs6596473 (n=3215) | |||||
| L ascorbic acid μmol/L |
CC | CG | GG | Per allele effect | p |
| 42.04 (40.72, 43.36) |
44.35 (42.86, 45.83) |
48.56 (45.31, 51.81) |
2.86 (1.39, 4.33) |
0.0001 | |
| Genotype at rs6596471 (n=3184) | |||||
| L ascorbic acid μmol/L |
TT | TC | CC | Per allele effect | p |
| 43.01 (41.73, 44.29) |
43.68 (42.17, 45.19) |
45.56 (41.55, 49.58) |
0.95 (−0.63, 2.53) |
0.2 | |
Means (95%CI) by genotype are adjusted for age.
Per allele effects and adjusted means are derived from linear regression.