Table 5.
Circulating L ascorbic acid by allelic variation at SCL23A1 in the European Prospective Investigation of Cancer study.
|
|
|||||
|---|---|---|---|---|---|
| Mean (95%CI) L-ascorbic acid |
|||||
| Genotype at rs33972313 (n=4501) | |||||
|
| |||||
| GG | GA | AA |
Mean difference
in L-ascorbic acid per minor allele |
p | |
| L ascorbic acid μmol/L |
56.66 (56.08, 57.24) |
48.21 (45.99, 50.43) |
43.38 (28.02, 58.73) |
−8.31 (−10.51, −6.11) |
1.7×10−13 |
|
| |||||
| Genotype at rs6596473 (n=4614) | |||||
|
| |||||
| CC | CG | GG |
Mean difference in
L-ascorbic acid per minor allele |
p | |
|
| |||||
| L ascorbic acid μmol/L |
55.54 (54.73, 56.35) |
56.90 (56.05, 57.75) |
57.09 (55.24, 58.94) |
1.01 (0.14, 1.87) |
0.02 |
|
| |||||
| Genotype at rs10063949 (n=4539) | |||||
|
| |||||
| AA | AG | GG |
Mean difference in
L-ascorbic acid per minor allele |
p | |
|
| |||||
| L ascorbic acid μmol/L |
56.16 (55.31, 57.01) |
56.19 (55.36, 57.03) |
55.98 (54.29, 57.68) |
−0.05 (−0.90, 0.80) |
0.9 |
Means (95% CI) by genotype are adjusted for age and sex.
Per allele effects and adjusted means are derived from linear regression.