Skip to main content
. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Nature. 2012 Sep 26;490(7420):355–360. doi: 10.1038/nature11438

Figure 4. Aged satellite cells are sensitive to acute changes of FGF signalling.

Figure 4

a-c, Strategy to delete Spry1 in SCs of adult (Ad) and aged (Ag) mice prior to injection of SU5402-coated beads (b) number of Pax7+ SCs/single muscle fibre (20-30 single muscle fibers/animal, n=4-6 mice/group) (c) percent Ki67+/Pax7+ SCs per 10μm cross-section 10 days post Tmx (n= 4-6 animals/group). d, Strategy to label and chase BrdU in SCs from Ad and Ag Ctrl or Spry1null mice 6 weeks post Tmx injection and Percent BrdU+/LRC SCs after chase. e, Strategy for BrdU incorporation in Tmx-treated Ctrl and Spry1OX aged mice and Percent BrdU+/SCs after chase. For panels d and e, n=1000 cells /condition, 4-6 mice/group. *P<0.05 ± s.e.m.