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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Nature. 2012 Sep 26;490(7420):355–360. doi: 10.1038/nature11438

Figure 5. Longer-term changes in FGF signalling drive satellite cell depletion.

Figure 5

a, Strategy to delete Spry1 Spry1 from SCs for 18 months and number of Pax7+ SCs /muscle section (n=30 sections/muscle, 5-6 animals/group). b, Spry1 deletion in aged SCs for 6 weeks and number of Pax7+ SCs/single muscle fibre (n=30 fibers/animal, 5-6 animals/group). c, Spry1 over-expression for 5 months in aged SCs and number of Pax7+ SCs/single muscle fibre from aged Ctrl and Spry1OX mice (20-30 single fibers/animal, 4-6 mice/group). d, Prior deletion of Spry1 for 6 weeks in aged SCs followed by muscle injury and H&E images of uninjured (0d) and 30 day (30d) regenerated muscles. e, Quantification of fibre size 30 days after BaCl2-induced injury (30d) and contra-lateral uninjured (0d) (scale-bar =25μm) (n=30 sections/muscle, 4-6 mice/group). *P<0.05 to 0d, #P<0.05 to Ctrl-30d, ± s.e.m. ANOVA with Bonferroni’s post-hoc test.