. 2013 Apr;168(7):1570–1583. doi: 10.1111/j.1476-5381.2012.02052.x

Table 1.

Structure of compounds, relative maximal ERK activity and hydrogen bonding energy between compounds and the homology model of the FFA1 receptor or GPR120

Compound	Structure	Relative maximum ERK response		H-bonding energy (arbitrary units)
Compound	Structure	FFA1	GPR120	FFA1	GPR120
α-LA		1.00	1.00^*	−5.73	−3.03^*
AMGEN-1		1.25	0.13	−7.48	−3.15
GW9508		0.80	0.28	−4.79	−2.83
MEDICA16		0.90	0.21^*	−5.91	−1.73^*
NCG20		0.93	1.38^*	−4.85	−4.04^*
NCG21		0.67	1.54^*	−5.09	−5.92^*
NCG22		0.64	0.93^*	−5.17	−5.07^*
NCG23		1.07	1.20^*	−6.58	−4.10^*
NCG25		1.26	1.25^*	−7.16	−4.73^*
NCG26		1.10	1.02^*	−5.87	−4.54^*
NCG27		0.61	0.55^*	−3.50	−2.23^*
NCG28		1.20	0.80^*	−5.69	−3.66^*
NCG29		0.17	1.46^*	−4.19	−3.56^*
NCG30		0.36	1.45^*	−3.46	−5.57^*
NCG31		0.13	1.40^*	−3.22	−4.06^*
NCG32		0.87	1.03^*	−5.34	−3.86^*
NCG33		0.04	0.39^*	−3.80	−2.88^*
NCG34		1.17	1.37^*	−5.78	−5.36^*
NCG35		1.30	1.48^*	−7.53	−4.75^*
NCG38		1.03	1.24^*	−6.87	−4.87^*
NCG39		0.42	1.23^*	−4.09	−4.75^*
NCG40		1.03	0.62^*	−5.42	−2.73^*
NCG41		1.61	0.96^*	−7.95	−2.61^*
NCG42		0.79	0.54^*	−3.46	−2.92^*
NCG44		0.32	0.64^*	−4.30	−3.10^*
NCG45		0.06	0.76^*	−3.33	−3.39^*
NCG46		0.53	1.20^*	−5.21	−5.41^*
NCG48		1.04	0.92^*	−6.15	−3.98^*
NCG49		0.89	0.75^*	−5.23	−2.61^*
NCG50		1.02	1.14^*	−3.96	−4.93^*
NCG51		0.95	1.32^*	−5.75	−4.77^*
NCG52		0.90	0.29^*	−4.29	−2.70^*
NCG53		1.47	1.27^*	−5.82	−4.56^*
NCG57		1.21	1.09^*	−6.98	−4.11^*
NCG74		1.64	0.66	−7.05	−1.67
NCG75		1.63	0.27	−6.77	−2.19
NCG85		1.45	0.86	−6.85	−3.52
NCG86		0.62	0.74	−3.37	−2.84
NCG87		0.99	0.10	−5.13	−1.11
NCG88		0.91	0.20	−6.89	−3.42
NCG89		0.86	0.11	−6.87	−0.76
NCG97		1.20	0.22	−6.57	−1.21
NCG98		0.89	0.19	−5.24	−1.65
NCG99		0.87	0.18	−5.82	−2.34
NCG100		0.18	0.11	−2.22	−3.08
NCG101		0.70	0.04	−4.36	−1.50
NCG102		0.80	0.05	−5.36	−1.27
NCG103		0.66	0.12	−3.24	−2.54
NCG104		0.63	0.02	−5.93	−1.00
NCG105		0.38	0.04	−3.19	−1.45
NCG106		0.66	0.07	−4.24	−0.18

The relative maximal ERK response was calculated as the relative value of the agonist response elicited by each compound (100 µM), with respect to the response evoked by 100 µM α-LA in FFA1 receptor- or GPR120-expressing cells.

Values from Sun et al. (2010).