Summary of the results using customized array-CGH and genome-wide array-CGH analyses in Patients 1, 2, and 3. Note that the genomic loss of copy number of EYA1 in the three patients on 8q13.3 identified on the clinical array-CGH (A, B, C circled). Fine mapping of the breakpoints using 244k Human Genome Agilent microarray, showing a 2.7 Mb deletion involving EYA1 and six other contiguous genes in Patient 1 (D), 3.6 Mb deletion in Patient 2 (E), and 8.7 Mb deletion in Patient 3 (F).