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Diverse pathological processes in SOD1-related FALS are highly interrelated and many stem directly from SOD1 misfolding/aggregation and cytosolic calcium overload. Abbreviations: mutSOD1, mutant SOD1; UTR, untranslated region; VDAC, voltage-dependent anion channel; ETC, electron transport chain; UPR, unfolded protein response; ROS/RNS, reactive oxygen/nitrogen species.
