TABLE I.
Locus | Chromosome | Gene | Characteristics | |
---|---|---|---|---|
Classical ALS | ALS1 | 12q22.1 | Superoxide dismutase 1 (SOD1) | AD, adult onset |
ALS2 | 2q33 | Alsin | AR, juvenile onset | |
ALS3 | 18q21 | Unknown | AD, adult onset | |
ALS4 | 9q34 | Senataxin (SETX) | AD, juvenile onset | |
ALS5 | 15q15.1–21.1 | Unknown | AR, juvenile onset | |
ALS6 | 16q12.1–12.2 | Fused in sarcoma (FUS) | AD, adult onset | |
ALS7 | 20p13 | Unknown | AD, adult onset | |
ALS8 | 20q13.33 | Vesicle-associated membrane protein-associated protein B (VAPB) | AD, adult onset | |
ALS9 | 14q11 | Angiogenin (ANG) | AD, adult onset | |
ALS10 | 1p36 | Tar DNA-binding protein (TARDBP) | AD, adult onset | |
Atypical ALS | ALSX | X | Unknown | XD, adult onset |
ALS/FTLD | 9q21–22 9p13.3–21.3 |
Unknown | XD, adult onset | |
ALS–PDC | 17q21.1 | Membrane-associated protein tau (MAPT) | AD, adult onset |
AD, autosomal dominant; AR, autosomal recessive; XD, X-linked dominant; FTLD, frontotemporal lobar dementia; PDC, Parkinsonism-dementia complex.
Updated references for each locus at the ALS Online Genetics Database (http://alsod.iop.kcl.ac.uk).
Gray-shaded areas are alternated with unshaded rows to improve readability of the table