TABLE I.

Genetic Loci Associated with ALS

	Locus	Chromosome	Gene	Characteristics
Classical ALS	ALS1	12q22.1	Superoxide dismutase 1 (SOD1)	AD, adult onset
	ALS2	2q33	Alsin	AR, juvenile onset
	ALS3	18q21	Unknown	AD, adult onset
	ALS4	9q34	Senataxin (SETX)	AD, juvenile onset
	ALS5	15q15.1–21.1	Unknown	AR, juvenile onset
	ALS6	16q12.1–12.2	Fused in sarcoma (FUS)	AD, adult onset
	ALS7	20p13	Unknown	AD, adult onset
	ALS8	20q13.33	Vesicle-associated membrane protein-associated protein B (VAPB)	AD, adult onset
	ALS9	14q11	Angiogenin (ANG)	AD, adult onset
	ALS10	1p36	Tar DNA-binding protein (TARDBP)	AD, adult onset
Atypical ALS	ALSX	X	Unknown	XD, adult onset
	ALS/FTLD	9q21–22 9p13.3–21.3	Unknown	XD, adult onset
	ALS–PDC	17q21.1	Membrane-associated protein tau (MAPT)	AD, adult onset

AD, autosomal dominant; AR, autosomal recessive; XD, X-linked dominant; FTLD, frontotemporal lobar dementia; PDC, Parkinsonism-dementia complex.

Updated references for each locus at the ALS Online Genetics Database (http://alsod.iop.kcl.ac.uk).

Gray-shaded areas are alternated with unshaded rows to improve readability of the table