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. Author manuscript; available in PMC: 2013 Mar 22.
Published in final edited form as: Brain. 2009 Mar 17;132(Pt 5):1161–1174. doi: 10.1093/brain/awp046

Figure 6.

Figure 6

Inverse correlation between global complex IV activity within multiple sclerosis lesions and the density of microglia/macrophages. When the global complex IV activity was densitometrically determined in 20× images, there is a significant inverse correlation (P = 0.001) between complex IV activity and the density of HLA reactive microglia and phagocytic macrophages. Furthermore, complex IV activity in the active rims or expanding edge of chronic active lesions (unfilled circles) is significantly lower (P < 0.001) compared with the inactive areas of chronic lesions (filled circles). The cell density is per 20× field. The densitometric values are corrected for background variation using normal appearing white matter.