Table III.

Comparison of lymphocyte subpopulations by morphometric analysis of histologic features and molecular phenotype

	Lymphocyte subpopulation, positive area/1.6 mm2 (mean ± standard deviation)a
Variable	CD3+ T-cells	CD79α+ B-cells	Total T/B-cells	CD3+/CD79α+ ratio
Histologic type	NS*	NS*	NS*	NS†
Simple	0.078 ± 0.102	0.027 ± 0.052	0.106 ± 0.143	0.277 ± 0.79
Complex	0.028 ± 0.032	0.008 ± 0.012	0.036 ± 0.033	14.38 ± 0.54
Mixed	0.043 ± 0.055	0.011 ± 0.012	0.055 ± 0.066	2.73 ± 0.58
Squamous cell	0.119 ± 0.120	0.028 ± 0.035	0.147 ± 0.144	3.36 ± 0.95
Lymphatic invasion	P = 0.008‡	P = 0.001‡	P = 0.005‡	NS§
Presence	0.118 ± 0.112	0.038 ± 0.049	0.157 ± 0.148	2.70 ± 0.72
Absence	0.055 ± 0.085	0.013 ± 0.031	0.067 ± 0.105	3.92 ± 1.02
Histologic grade	P = 0.035*	P = 0.011*	P = 0.020*	NS†
I	0.025 ± 0.047	0.003 ± 0.004	0.029 ± 0.047	3.05 ± 1.04
II	0.072 ± 0.087	0.023 ± 0.040	0.096 ± 0.119	4.31 ± 0.99
III	0.118 ± 0.119	0.035 ± 0.049	0.153 ± 0.152	2.72 ± 0.73
Necrosis	NS‡	NS‡	NS‡	NS§
Presence	0.103 ± 0.113	0.027 ± 0.045	0.131 ± 0.143	3.26 ± 0.85
Absence	0.055 ± 0.080	0.020 ± 0.037	0.075 ± 0.113	3.01 ± 0.84
Molecular phenotype	NS*	NS*	NS*	NS†
Luminal A	0.028 ± 0.043	0.005 ± 0.007	0.033 ± 0.045	5.84 ± 0.59
Luminal B	0.133 ± 0.141	0.049 ± 0.052	0.182 ± 0.181	2.53 ± 0.76
Basal	0.111 ± 0.111	0.038 ± 0.059	0.148 ± 0.157	2.91 ± 0.83
HER-2-overexpressing	0.076 ± 0.095	0.016 ± 0.015	0.092 ± 0.097	2.09 ± 0.76

^aStatistical significance determined by

^*the Kruskal–Wallis test,

^†analysis of variance,

^‡the Mann–Whitney U-test, and

^§Student’s t-test.