TABLE 1.

Simulated parameters representing the contributions of TAG biosynthesis pathways and the selectivity of reacylation manifest in mouse organs

Sample	K1	K2	K3	k1	k2	k3	γ
Skeletal muscle	0	1.000	0	0.11 ± 0.09	0.05 ± 0.05	0.01 ± 0.01	0.977 ± 0.007
Heart	0.145 ± 0.033	0.825 ± 0.043	0.030 ± 0.014	0.01 ± 0.01	0	0	0.960 ± 0.015
Liver	0.493 ± 0.031	0.507 ± 0.031	0	0.47 ± 0.15	0.23 ± 0.05	0	0.943 ± 0.007

The determined TAG levels of mouse skeletal muscle, heart, and liver by MDMS-SL (supplementary Table I) were simulated with the TAG biosynthesis pathways as illustrated in Fig. 1. The parameters of K₁, K₂, and K₃ represent the contributions of individual pathways (i.e., PA-, MAG-, and PI-DAG pathways, respectively) to the TAG pools. The parameters of k₁, k₂, and k₃ represent the degrees of acyltransferase selectivity to the different fatty acyl chains at the sn-1, 2, and 3 positions of TAG species, respectively (see text for details).