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. 2013 Apr;54(4):1103–1113. doi: 10.1194/jlr.M034744

Fig. 5.

Fig. 5.

Effect of initial monolayer surface pressure and BODIPY-glycolipid surface density in PC or PE matrix on glycolipid uptake rate by GLTP. A: Uptake rates of B15-GalCer (1 mol%) by GLTP (0.6 µM) from either POPE or POPC monolayers poised at different initial surface pressures. GLTP uptake of B15-GalCer is ∼7-fold faster from POPE than from POPC monolayers at 24 mN/m. B: B15-GalCer surface densities in POPE and POPC monolayers and removal rates by GLTP. For each lipid matrix, higher surface density of glycolipid slows its removal rate, but much faster removal occurs from POPE than POPC at similar glycolipid surface densities. Data for (A) and (B) were derived from the symbol-delineated regions of Fig. 4C and D, respectively. Additional data showing the surface pressure versus molecular area isotherms used to calculate lipid surface densities of POPC and POPE matrices and the impact of POPC and POPE surface density on the B15-GalCer uptake rate by GLTP are provided in supplementary Fig. II.