TABLE 1.

Genes downregulated in knockout versus WT myocardium

Process	Gene Symbol	Gene Description	F.C.	P
Acyl CoA formation/hydrolysis/binding	Acsm5	Acyl-CoA synthetase medium-chain family member 5	−2.4	1.1E-04
	Acsl6	Acyl-CoA synthetase long-chain family member 6	−1.9	4.6E-04
	Acot1	Acyl-CoA thioesterase 1	−1.7	4.2E-04
	Lpcat3	Lysophosphatidylcholine acyltransferase 3	−1.7	1.2E-05
	Acss1	Acyl-CoA synthetase short-chain family member 1	−1.4	6.1E-04
Mitochondrial β-oxidation/oxidative phosphorylation	Scd4	Stearoyl-CoA desaturase 4	−3.0	9.2E-07
	Ucp3	Uncoupling protein 3 (mitochondrial, proton carrier)	−2.9	7.6E-04
	Acaa2	Acetyl-CoA acyltransferase 2 (mitochondrial 3-oxoacyl-CoA thiolase)	−2.0	1.7E-04
	Slc25a20	Solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20	−1.7	4.2E-04
	Fads3	Fatty acid desaturase 3	1.6	3.1E-04
	Acadsb	Acyl-CoA dehydrogenase, short/branched chain	−1.4	7.4E-04
	Acss1	Acyl-CoA synthetase short-chain family member 1	−1.4	6.1E-04
	Fh1	Fumarate hydratase 1	−1.4	1.1E-03
	Ndufs8	NADH dehydrogenase (ubiquinone) Fe-S protein 8	−1.4	1.1E-03
Ketogenesis	Hmgcs2	3-Hydroxy-3-methylglutaryl-CoA synthase 2	−1.9	1.4E-04
	Ech1	Enoyl CoA hydratase 1, peroxisomal	−1.7	1.8E-04
	Acat1	Acetyl-CoA acetyltransferase 1	−1.5	1.1E-03
Peroxisomal β-oxidation	Peci	Peroxisomal delta3, delta2-enoyl-CoA isomerase	−1.5	4.2E-04
Lipases	Ces3	Carboxylesterase 3	−2.5	1.2E-04
	Lipe	Lipase, hormone sensitive	−1.5	5.8E-01
Biotransformation	Ephx2	Epoxide hydrolase 2, cytoplasmic	−1.5	2.9E-04

Enriched biological processes of genes were differentially expressed in myocardium of MCH-Plin5 versus WT control mice. F.C., fold change.