TABLE 2.

Genes upregulated in knockout versus WT myocardium

Process	Gene Symbol	Gene Description	F.C.	P
Oxidative stress via Nrf2 pathway	Gsta1	Glutathione S-transferase, α 1 (Ya)	12.18	3.5E-09
	Gsta2	Glutathione S-transferase, α 2 (Yc2)	7.00	6.9E-08
	Atf4	Activating transcription factor 4	2.83	9.7E-07
	Esd	Esterase D/formylglutathione hydrolase	2.20	5.0E-06
	Txnrd1	Thioredoxin reductase 1	1.93	6.0E-05
	Hmox1	Heme oxygenase (decycling) 1	1.93	2.3E-04
	NQO1	NAD(P)H dehydrogenase, quinone 1	1.80	3.8E-04
	Gss	Glutathione synthetase	1.75	4.8E-06
	Por	P450 (cytochrome) oxidoreductase	1.53	3.6E-04
	Gclc	Glutamate-cysteine ligase, catalytic subunit	1.53	9.0E-04
	Mafk	V-maf musculoaponeurotic fibrosarcoma oncogene  family, protein K (avian)	1.50	6.8E-04
	Gpx4	glutathione peroxidase 4	1.39	3.3E-04
Early heart failure markers	Asns	asparagine synthetase	22.07	2.7E-11
	Mthfd2	Methylenetetrahydrofolate dehydrogenase (NAD+ dependent),  methenyltetrahydrofolate cyclohydrolase	20.65	1.4E-10
	Maoa	Monoamine oxidase A	6.11	3.0E-04
	Gdf15	Growth differentiation factor 15	5.90	4.5E-04
	Myc	Myelocytomatosis oncogene	4.93	3.5E-07
	Uchl1	Proteasome	4.62	1.2E-03
	Chac1	ChaC, cation transport regulator-like 1 (E. coli)	4.46	3.1E-07
	Atf5	Activating transcription factor 5	3.31	2.2E-06
	Trib3	Tribbles homolog 3 (Drosophila)	2.92	2.3E-06
	Grk5	G protein-coupled receptor kinase 5	1.88	7.3E-04
Cytoskeleton organization	Acta1	Actin, α 1, skeletal muscle	3.72	2.1E-06
	Mtap1a	Microtubule-associated protein 1A	3.38	2.8E-06
	Ttll7	Tubulin tyrosine ligase-like family, member 7	2.72	4.3E-05
	Mtap1b	Microtubule-associated protein 1B	2.56	4.0E-04
	Tubgcp4	Tubulin, γ complex-associated protein 4	2.07	3.9E-05
	Flnc	Filamin C, γ	2.05	1.2E-05

Enriched biological processes of genes were differentially expressed in myocardium of MCH-Plin5 versus WT control mice. F.C., fold change.