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. 2012 Nov 30;22(5):1050–1058. doi: 10.1093/hmg/dds504

Figure 2.

Figure 2.

FTO and shared variance between brain volume and BMI determinants in the SYS-Discovery, SYS-Replication and IMAGEN samples. (A) Two significant components (and their respective loadings) identified with PCA involving four variables (i.e. brain volume, TBF, LBM and height) in the SYS-Discovery and SYS-Replication samples and three variables (i.e. brain volume, body weight and height) in the IMAGEN sample are presented. Component 1 explained 50.6, 54.9 and 54.5% of variance in the SYS-Discovery, SYS-Replication and IMAGEN samples, respectively. Component 2 explained 25.0, 22.6 and 31.0% of variance in the SYS-Discovery, SYS-Replication and IMAGEN samples, respectively. (B) Association between FTO (rs9930333) and each of the two significant components were tested with Merlin-1.1.2.