Table 3.
Meta-analysis of FTO associations in the SYS (discovery and replication) and IMAGEN samples
| Outcome | Effect size ± SE (G allele) | P-value | HetISq | Heterogeneity P-value |
|---|---|---|---|---|
| BMI (log kg/m2) | −0.020 ± 0.003 | 8.9 × 10−11 | 0.0 | 0.98 |
| Body weight (log kg) | −0.015 ± 0.003 | 8.1 × 10−8 | 0.0 | 0.60 |
| Brain volume (cm3) | 12.8 ± 3.4 | 1.5 × 10−4 | 0.0 | 0.68 |
| IC volume (cm3) | 10.6 ± 4.8 | 0.03 | 0.0 | 0.53 |
| Component 2 | 0.22 ± 0.04 | 1.3 × 10−9 | 32.1 | 0.23 |
Meta-analysis was performed with METAL. Component 2: principal component 2 from PCA of brain volume and BMI determinants (i.e. TBF, LBM and height).
HetISq: I2 statistic that measures heterogeneity on scale of 0–100%. SE, standard error.