Figure 10.

Hu97/18 mice display neuropathological abnormalities consistent with HD. The brains of 12-month-old mice were evaluated for physical changes seen in HD. (A) Hu97/18 trend toward reduced forebrain weight (P = 0.07), (B) but have no change in cerebellum weight. Stereological analysis shows that compared with Hu18/18 mice, Hu97/18 mice have significantly decreased (C) striatal and (D) cortical volume and (E) a trend toward reduced corpus callosum volume. (F) There is also a trend toward reduced DARPP-32 staining intensity in the Hu97/18 brain. **P < 0.01.