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Body weight is increased in both Hu18/18 and Hu97/18 mice. Body weight was assessed at 2 month intervals in (A) male and (B) female Hu97/18 and Hu18/18 mice and compared with historical FVB body weight data (unpublished). While Hu97/18 mice are slightly heavier than Hu18/18 mice, both humanized genotypes are significantly heavier than wt mice. Different from FVB: *P < 0.05 and ***P < 0.001; different from Hu18/18: #P < 0.05.
