. 2012 Sep 21;22(1):18–34. doi: 10.1093/hmg/dds397

Table 2.

Summary of HD-like phenotypes of Hu97/18 and BACHD mice

Phenotype	Onset (months) Hu97/18	BACHD	References
Body weight	4	3	(33)
Rotarod learning	2^a	2^a	(24)
Rotarod	4	4	(33)
Climbing	2^a	6^a	(34)
Spontaneous activity	2^a	1^a	(41)
Open-field exploration	3^a	6^a	(34)
Elevated plus maze	6	3^a	(36)
Forced swim	12^a	12^a	(33)
Spatial learning	6	6^a	(34)
Object recognition	9	6^a	(34)
Forebrain weight	P = 0.07 12^a	12^a	(33)
Striatal volume	12^a	12^a	(24)
Cortical volume	12^a	12^a	(24)
Corpus callosum	no change 12^a	ND
DARPP-32 staining	P = 0.09 12^a	no change 7^a	(34)

ND, not determined. Age of onset (months) of HD-like behavioral and neuropathological phenotypes of full-length human BACHD-derived muHTT transgenic HD mouse models. BACHD mice are compared with WT littermates, and Hu97/18 mice are compared with Hu18/18 littermates.

^aEarliest evaluated time point.