Fig. 3.—

Structure of the LAVA element. (A) Illumina reads obtained from hoolock BACs and known for containing SVA sequences were mapped against the SVA consensus sequence. Most of the reads map in correspondence of the VNTR region of the SVA element. (B) Structure of the novel composite TE based on the sequence data obtained from NLE BACs. The arrows inside the different components indicate their orientation. (C) The PCR product spanning the junction between the AluSz6 and L1ME5 regions was labeled and used as probe for FISH on hoolock metaphases. The bright centromeric signals confirm that the novel TE is expanded in the hoolock centromeres.