Table 4. Intermolecular dimer contacts in wtGLTP and the D48V mutant complexed with 12:0 monoSF, crystal form 1.
Structure elements and residues involved in dimeric contacts are given. Only close contacts are considered, with a contact distance of 4.
| wt | D48V | |
|---|---|---|
| 66 | ||
| Trp142* | Tyr153 | Tyr153 |
| Ile143* | Ala150, Tyr153, Ala154 | Ala150, Tyr153 |
| Lys146* | Ala150 | |
| Ile147* | Ile147, Ala150 | |
| Ala150* | Ile143, Lys146, Ile147 | lle143 |
| Ala154* | Ile143 | |
| Tyr153* | Trp142, Ile143 | Trp142, Ile143 |
| Contacts | 25 | 16 |
| 22 | ||
| Pro44* | Pro44, Val48 | |
| Ala47* | Ala47, Val48 | |
| Val48* | Pro44, Ala47 | |
| Contacts | 0 | 26 |
| (Tip of 2)6 | ||
| Val41* | Val144 | Ile143, Val144 |
| Contacts | 2 | 4 |
| (Tip of 2)C-end | ||
| Pro40* | Val209 | Val209 |
| Contacts | 2 | 18 |
| Lipidlipid | ||
| Contacts | 6 | 3 |
| Lipidprotein | ||
| Lipid | Val41, Ile45, His140, Ile147, Phe148, Ala151 | Pro40, Thr43, Pro44, Ile147 |
| Contacts | 40 | 18 |