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. 2010 Jun 16;30(24):8251–8262. doi: 10.1523/JNEUROSCI.5361-09.2010

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Copyright © 2010 the authors 0270-6474/10/308251-12$15.00/0

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Figure 1. — Exogenous application of either SP or NK1 agonist facilitates respiratory population activity recorded in medullary slice preparation containing the pre-BötC. Shown are effects of SP and NK1 agonist Sar,Met-SP on respiratory rhythmic activity recorded in a portion of the VRG containing the pre-BötC in vitro. A, B, Two traces of integrated activity obtained from extracellular population activity recorded from the surface of a portion of the VRG that contains the pre-BötC. Upward deflections reflect bursts of fictive inspiratory activity. Note that application of 30 nm SP (A) and 100 nm Sar,Met-SP (B) facilitates respiratory activity. C, D, Graphs indicating that SP (C) and Sar,Met-SP (D) enhance respiratory rhythmic activity in a dose-dependent manner (collected number is shown in each bar graph).