Table 2. Interface parameters of PCNA.
Calculated using the PISA server (Krissinel & Henrick, 2005 ▶) and the SC program (Lawrence & Colman, 1993 ▶). The values for the heterotrimers and dimers are averaged over all of the molecules in the asymmetric units. The numbers of hydrogen bonds and salt bridges are listed for the interfaces in the three rings.
| Interface | Area (Å2) | Shape complementarity† | Hydrogen bonds | Salt bridges |
|---|---|---|---|---|
| PCNA1–PCNA2 | 1404.0 | 0.80 | 12/14/12 | 8/7/10 |
| PCNA2–PCNA3 | 1212.4 | 0.55 | 7/7/8 | 3/4/1 |
| PCNA3–PCNA1 | 1294.4 | 0.68 | 11/7/8 | 1/0/2 |
| PCNA1–PCNA2 (dimer) | 1393.0 | 0.77 | 9/13 | 11/8 |
| P. furiosus PCNA | 1438.6 | 0.68 | 14 | 14 |
| S. cerevisiae PCNA‡ | 1317.4 | 0.61 | 8 | 3 |
| Human PCNA | 1384.8 | 0.68 | 12 | 1 |
†
Shape complementarity (SC) is in the range 0–1. Interfaces with a SC of 1 match precisely, while interfaces with SC ≃ 0 are uncorrelated in their topography.
‡
Krishna et al. (1994 ▶).