Table 2. Tabulation of phenotypes for tel1-Δ interactions identified in the MMS screen.

	Strain	MMS interaction	IR interaction	GCR	Short telomere	CDC13-EST2 rescue	Description
Class 1	rad24-Δtel1-Δ	++	+	++	++	+/−	9-1-1 complex
	rad17-Δtel1-Δ	++	+	++	++	+/−	9-1-1 complex
	ddc1-Δtel1-Δ	++	+	++	++	+/−	9-1-1 complex
Class 2	nup60-Δtel1-Δ	+	—	+	+	—	Nucleoporin
	rad27-Δtel1-Δ	+	—	+	+	—	Flap endonuclease
	sap30-Δtel1-Δ	+	—	—	+	—	Deacetylase
	pop2-Δtel1-Δ	+	—	—	+	—	Deadenylase
	ccr4-Δtel1-Δ	+	—	—	+	—	Deadenylase
	hda3-Δtel1-Δ	+	—	—	+	—	deacetylase
	yku80-Δtel1-Δ	+	—	—	+	—	NHEJ
	nup133-Δtel1-Δ	+	—	—	+	—	Nucleoporin
Class 3	lsm7-Δtel1-Δ	+	—	—	—	—	mRNA decap
	rad26-Δtel1-Δ	+	—	—	—	—	TCR

For each of the tel1-Δ xxx-Δ genetic interactions identified in the MMS screen a “+” indicates whether a double mutant exhibited a positive result in each of the assays tested (e.g., increased GCR frequency, shorter telomere, etc.); a “++” indicates a more severe phenotype; and a “+/−” indicates partial suppression. TCR, transcription-coupled repair.