Table 2. Summary of Published and Experimental Findings.

Experiment	Gene (Protein)
	BMEI0454(OmpW)	BMEI0657(BtuB)	BMEI071(Omp22)	BMEI1872(Hia)	BMEI0160(FlgK)	BMEI0536(Bp26)
16M Transcriptomics
Bovinea	15 m: −2.01	15 m: +1.68	15 m: −6.95	15 m: −13.63	15 m: +2.51	N/A
	120 m: −1.72	120 m: +3.44	120 m: −8.13	120 m: −11.86	120 m: +2.69
HeLa [19]	4 h: −9.97	4 h: +2.66	4 h: −5.63	4 h: −2.36	4 h: +2.94	N/A
	12 h: −21.03	12 h: +2.58	12 h: −6.15	12 h: −1.74	12 h: +3.7
16M Mutagenesis [15]	N/A	Attenuated	N/A	N/A	N/A	N/A
BvrR/S- B. abortus [31], [32]	–	–	–	N/A	N/A	N/A
Immunoreactivity b
Human	2.2	2.4	2.7	3	3.1	2.2
Mouse	5.2	1.3	3.6	3.2	1.5	3.5
Goat	3.5	1.8	6	2.1	0.6	3.3
Vaxign Program [23]
Adhesin Probability	0.586	0.504	0.609	0.656	0.39	N/A
Human MHCI score	0.296545	0.361865	0.263562	0.288301	0.339568	N/A
Human MHCII Score	0.32461	0.382724	0.30115	0.344729	0.337355	N/A
Mouse MHCI Score	0.341885	0.416492	0.314076	0.345491	0.392729	N/A
Mouse MHCII Score	0.310426	0.37862	0.291076	0.359367	0.353167	N/A
Outer Membrane Score	1	1	0.992	0.992	0.949	N/A
Additional notes				Homology toColonization	Role in Chronic	Immunogenic in
				Factor inH. Influenzae [33]	Infection in Mice [67]	Goat/Human [68]

^aRosseti, CA, et. al., manuscript in preparation.

^bImageJ analysis.

(−) gene or protein is down regulated.

16M- Brucella melitensis 16M.

N/A- not available.