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. Author manuscript; available in PMC: 2013 Oct 15.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Sep 11;51(42):10500–10504. doi: 10.1002/anie.201205475

Figure 4.

Figure 4

Light-dependent anesthesia in tadpoles. Loss of righting reflexes is plotted against aqueous anesthetic concentration, overlayed with logistic fits. Each point represents data from ten animals. a) 360–370 nm light, an apparently noxious stimulus in Xenopus tadpoles, produces a small rightward shift in propofol-dependent loss of righting reflexes (LORR) from 1.1 ± 0.1 μM (circles) to 2.0 ± 0.1 μM (stars). b) 360–370 nm light shifts the AP2-dependent LORR curve to the right from 1.1 ± 0.1 μM (squares) to 4.6 ± 0.2 μM (X’s). This larger shift is due to photo-isomerization of AP2.