Skip to main content
. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Nanomedicine. 2012 Nov 22;9(4):558–569. doi: 10.1016/j.nano.2012.10.010

Figure 4.

Figure 4

CONP treatment prior to, but not post, RT increase RT-induced ROS levels in acidic pancreatic cancer cells and decrease RT-induced ROS levels in neutral pancreatic normal cells. (A&B) The cancer (L3.6pl) and normal hTERT-HPNE cells were treated with (CONP) or without (Ctrl) CONPs for 24 hours followed by 5 Gy RT. ROS levels were then determined and compared between the cells at indicated times. Relative fold changes were normalized to the control groups. (C&D) The cells were treated with 5 Gy RT for 24 hours prior to CONP treatment. ROS levels were then determined and compared between the cells at indicated times. Relative fold changes are normalized to the control groups. *P < 0.001. The acidic cancer cellular environment relative to the neutral normal cellular environment was confirmed (see Figure S5)