Table 1.

CONPs Increase Sensitivity to Radiation-Induced Inhibition of Human Pancreatic Tumor Growth

Treatment Group	Tumor					Body Weight (g)
	Incidence	Volume (mm3)		Weight (g)		Mean	Range
		Mean	Range	Mean	Range
Control	15/15	2100	1750–3000	1.31	0.48–2.63	28	22–32
RT	15/15	1643	1000–2000	1.38	1.04–2.26	26	20–31
CONP	15/15	1306†	1000–2500	1.39	0.71–2.40	26	20–37
CONP + RT	15/15	1045*†	250–2000	0.97*†	0.23–1.66	27	21–31

L3.6pl cells (1 × 10⁶) were injected into the pancreas of nude mice. Groups of mice were treated with i.p injections of saline (control) or CONP (15 μM or 0.01 mg/kg) twice weekly for 6 weeks. Sub-groups of mice also received fractionated RT (5 Gy) three times per week (total 30 Gy) during weeks 3 and 4. All mice were sacrificed on day 56. Tumor weight and volume analysis were performed as described in methods.

^*P< 0.01 compared to RT.

^†P < 0.01 compared to control.