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. 2013 Mar 22;8(3):e60185. doi: 10.1371/journal.pone.0060185

Figure 2. RGS10 gene structure.

Figure 2

A. The RGS10 gene (geneID: 6001) is located on the negative strand of chromosome 10 (NCBI accession: NC_000010.10) at position −121,302,222 to −121,259,339. Two transcription variants RGS10-1 (accession: NM_001005339) and RGS10-2 (accession: NM_002925) have been reported for RGS10 based on alternate start sites that result in distinct first exons. B. The resulting protein isoforms RGS10a (accession: NP_001005339) and RGS10b (accession: NP_002916) vary by only the first 18 or three amino acids. The conserved RGS domain is underlined. C.–D. The expression of total RGS10 transcript (RGStot), RGS10-1, and RGS10-2 were determined in IOSE and CAOV-3 cells (C) and in parental A2780 cells and chemoresistant A2780-AD cells (D). **: p<0.01, ***: p<0.0001.