Table 4.
Mean number (± SD) of aberrant crypt foci (ACF) and aberrant crypt (AC) observed in the distal colon of rats treated with the C. langsdorffii extract and DMH
|
Treatments (mg/kg) |
Number of ACF |
Number of ACF |
Number of AC |
AC/ACF |
|||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||||
| DMH |
9.2 ± 1.2 |
3.2 ± 1.3 |
1.2 ± 0.9 |
0.5 ± 0.8 |
14.0 ± 1.4 |
20.8 ± 1.9 |
1.5 ± 0.1 |
| DMSO + DMH |
6.7 ± 2.6 |
3.5 ± 1.9 |
2.2 ± 1.5 |
0.3 ± 0.8 |
12.8 ± 3.5 |
21.0 ± 5.9 |
1.6 ± 0.2 |
| 20 + DMH |
7.2 ± 1.6 |
4.8 ± 1.7 |
2.2 ± 0.8 |
0.2 ± 0.4 |
14.3 ± 2.7b |
23.7 ± 5.3b |
1.6 ± 0.2 |
| 40 + DMH |
6.2 ± 2.3 |
4.0 ± 0.7 |
0 |
0.4 ± 0.5 |
10.6 ± 1.9a |
15.8 ± 2.9a |
1.5 ± 0.2 |
| 80 + DMH | 4.7 ± 0.8 | 2.7 ± 1.2 | 0.7 ± 0.8 | 0.2 ± 0.4 | 8.0 ± 1.9a | 12.0 ± 4.0a | 1.5 ± 0.2 |
DMH, 1,2-dimethylhydrazine (160 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in g/kg.
*Values are the mean ± standard deviation.
aSignificantly different from the DMH group (P < 0.05).
bSignificantly different from the 40 + DMH and 80 + DMH groups (P < 0.05).