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. 2013 Mar 15;9:13. doi: 10.1186/1744-9081-9-13

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Copyright ©2013 Xiong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rotenone activated autophagy in SH-SY5Y. LC3/P62 immunoblotting was used to track the conversion of LC3-I into LC3-II and the expression of P62 for autophagic activity. (A) The immunoblotting of LC3-II/LC3-I, P62 and β-actin from Con-, Rot-0.5μM, Rot-1μM, Rot-2.5μM, Rot-5μM and Rot-10μM groups; (C), (D) Quantitative analysis of immunoblotting of LC3-II/LC3-I and P62 both controlled by β-actin, respectively. (B) The immunoblotting of LC3- II/I, P62 and β-actin in a Rot (2.5μM) time-dependent manner from Con-, Rot-3h, Rot-6h, Rot-12h, Rot-24h, Rot-36h and Rot-48h groups; (E), (F) Quantitative analysis of immunoblotting of LC3-II/LC3-I, P62 controlled by β-actin (*P < 0.05, compared to Con-group).