Table 2. Baseline characteristics in men and women stratified by SUA quartiles.
| Men | Women | |||||||||
| Q1 | Q2 | Q3 | Q4 | P-value | Q1 | Q2 | Q3 | Q4 | P-value | |
| Number of patients | 1406 | 1423 | 1385 | 1398 | 1056 | 1028 | 1017 | 1029 | ||
| Age (years) | 62.8 (6.0) | 63.3 (6.2) | 63.6 (6.2) | 63.5 (6.2) | 0.004 | 62.6 (5.9) | 63.1 (5.9) | 63.1 (6.2) | 63.9 (6.2) | <0.0001 |
| History of CVD (%) | 77.9 | 81.5 | 85.6 | 87.4 | <0.0001 | 57.8 | 63.7 | 65.0 | 69.6 | <0.0001 |
| Diabetes (%) | 85.4 | 79.8 | 79.8 | 80.8 | 0.003 | 86.5 | 82.3 | 86.9 | 90.0 | 0.002 |
| Total Cholesterol (mmol/l) | 184.4 (40.4) | 183.8 (41.0) | 185.6 (42.0) | 189.3 (44.0) | 0.002 | 206.4 (44.1) | 207.8 (44.5) | 205.9 (44.7) | 207.7 (44.0) | 0.70 |
| Triglycerides (mmol/l) | 195.9 (138.7) | 194.8 (124.1) | 204.3 (123.3) | 226.9 (148.5) | <0.0001 | 173.7 (94.2) | 181.8 (90.8) | 198.5 (119.9) | 218.5 (106.3) | <0.0001 |
| Blood glucose (mmol/l) | 9.2 (3.5) | 8.3 (2.9) | 8.0 (2.7) | 8.0 (2.7) | <0.0001 | 9.2 (3.8) | 8.5 (3.4) | 8.4 (3.1) | 8.3 (3.0) | <0.0001 |
| HgbA1c* | 7.9 (1.5) | 7.4 (1.3) | 7.2 (1.3) | 7.2 (1.3) | <0.0001 | 8.0 (1.6) | 7.5 (1.5) | 7.4 (1.4) | 7.4 (1.4) | <0.0001 |
| BMI (kg/m2) | 33.2 (4.0) | 33.6 (4.1) | 33.7 (4.1) | 34.2 (4.2) | <0.0001 | 34.7 (5.0) | 35.2 (4.6) | 36.0 (4.7) | 36.3 (4.9) | <0.0001 |
| Systolic blood pressure (mmHg) | 137.5 (12.5) | 137.5 (13.3) | 137.5 (12.9) | 137.1 (13.1) | 0.82 | 139.5 (12.7) | 139.9 (12.1) | 139.2 (12.5) | 138.6 (12.1) | 0.10 |
| Diast. blood pressure (mmHg) | 78.3 (8.2) | 78.5 (8.5) | 78.3 (8.5) | 78.1 (8.5) | 0.73 | 77.2 (8.0) | 77.7 (8.3) | 77.7 (8.4) | 76.4 (8.7) | 0.0007 |
| Diuretics users (%) | 33.0 | 39.1 | 43.8 | 61.5 | <0.0001 | 36.3 | 46.0 | 56.5 | 70.1 | <0.0001 |
| Beta-blocker users (%) | 59.7 | 64.0 | 66.1 | 70.8 | <0.0001 | 50.4 | 55.2 | 57.8 | 61.8 | <0.0001 |
| Statin users (%) | 67.1 | 70.3 | 70.8 | 74.0 | <0.0001 | 57.9 | 61.4 | 62.2 | 63.0 | 0.016 |
| Aspirin users (%) | 84.0 | 84.5 | 87.3 | 87.9 | 0.0005 | 66.1 | 66.3 | 68.6 | 73.6 | 0.0001 |
| Sibutramine users (%) | 49.9 | 50.0 | 50.0 | 48.7 | 0.57 | 50.9 | 48.5 | 52.1 | 50.6 | 0.68 |
| Smokers (%) | 70.7 | 74.9 | 76.2 | 76.4 | 0.0004 | 30.3 | 35.9 | 37.1 | 40.6 | <0.0001 |
| Alcohol users (%) | 75.2 | 75.0 | 79.7 | 80.4 | <0.0001 | 35.5 | 39.7 | 44.0 | 40.7 | 0.004 |
| Primary outcome event (%) | 12.4 | 10.9 | 12.1 | 14.7 | 0.035 | 7.9 | 6.2 | 7.3 | 11.6 | 0.002 |
| All-cause mortality (%) | 8.4 | 8.6 | 9.5 | 12.7 | <0.0001 | 5.1 | 4.2 | 5.5 | 11.1 | <0.0001 |
Continuous variables are presented as means (SD). Abbreviations: Q1 = lowest quartile: males: <317 µmol/l, females: <280 µmol/l, Q2 = second quartile: males: 317–373 µmol/l, females: 280–336 µmol/l, Q3 = third quartile: males: 373–432 µmol/l, females: 336–395 µmol/l, Q4 = highest quartile males: >432 µmol/l, females: >395 µmol/l. BMI = body mass index. Diast. = diastolic.
P-values were obtained by analysis of variance for continuous variables and by Cochran-Armitage trend test for discrete variables.
*
HbA1c was only measured in diabetics.