Table 3. Hazard ratios and 95% confidence intervals for men and women calculated by Cox regression.

Event	SUA	Model 1	Model 2	Model 3	Model 4
Primary outcome event, men	Q1	1 (ref)	1 (ref)	1 (ref)	1 (ref)
	Q2	0.87 (0.70–1.08)	0.85 (0.69–1.06)	0.81 (0.65–1.01)	0.84 (0.67–1.05)
	Q3	0.99 (0.80–1.22)	0.96 (0.78–1.19)	0.88 (0.71–1.09)	0.90 (0.72–1.11)
	Q4	1.22 (1.00–1.50)	1.19 (0.97–1.46)	0.95 (0.76–1.17)	0.96 (0.77–1.20)
Primary outcome event, women	Q1	1 (ref)	1 (ref)	1 (ref)	1 (ref)
	Q2	0.80 (0.58–1.10)	0.78 (0.56–1.08)	0.71 (0.51–0.98)	0.73 (0.52–1.01)
	Q3	0.95 (0.70–1.30)	0.93 (0.68–1.27)	0.78 (0.56–1.07)	0.76 (0.54–1.05)
	Q4	1.59 (1.20–2.10)	1.49 (1.12–1.97)	1.03 (0.75–1.39)	0.99 (0.72–1.36)
Cardiovascular death, men	Q1	1 (ref)	1 (ref)	1 (ref)	1 (ref)
	Q2	1.12 (0.79–1.59)	1.09 (0.77–1.54)	1.01 (0.71–1.43)	1.01 (0.71–1.44)
	Q3	1.36 (0.97–1.90)	1.30 (0.93–1.83)	1.13 (0.81–1.59)	1.13 (0.79–1.60)
	Q4	1.88 (1.37–2.58)	1.81 (1.32–2.49)	1.28 (0.92–1.79)	1.26 (0.89–1.78)
Cardiovascular death, women	Q1	1 (ref)	1 (ref)	1 (ref)	1 (ref)
	Q2	0.55 (0.31–0.99)	0.54 (0.30–0.97)	0.48 (0.26–0.86)	0.51 (0.28–0.92)
	Q3	0.94 (0.57–1.56)	0.92 (0.55–1.52)	0.74 (0.44–1.24)	0.73 (0.43–1.24)
	Q4	2.11 (1.37–3.24)	1.97 (1.28–3.03)	1.28 (0.80–2.04)	1.31 (0.80–2.13)

Cut off points for quartiles: see Table 2. Ref = reference. Hazard ratios (95% confidence intervals). Primary outcome event = AMI, stroke, resuscitation after cardiac arrest or cardiovascular death.

^*Hazard ratios with p-values less than 0.05 are written in bold letters.

Model 1: uric acid.

Model 2: model 1+ age.

Model 3: model 2+ baseline serum creatinine and diuretics use.

Model 4: model 3+ baseline values of cholesterol, HDL-C, LDL-C, BMI, glucose, triglyceride, history of only diabetes/both diabetes and cardiovascular disease/only cardiovascular disease, history of congestive heart failure, systolic blood pressure, diastolic blood pressure, waist-hip ratio, tobacco use, alcohol use, beta-blocker use, statin use, aspirin use and sibutramine use.