Table 2.
Selected genes from skin of RH patients significantly over- or under expressed in comparison with skin from NC, in ascending order of fold change (NC/RH)
| Gene symbol | Fold change | Gene name |
|---|---|---|
| GREM1 | 0.49 | Gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) |
| TP63 | 0.5 | Tumor protein p63 |
| KRT15 | 0.53 | Keratin 15 |
| TFAP2C | 0.59 | Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
| KLF5 | 0.63 | Kruppel-like factor 5 (intestinal) |
| ELL2 | 0.66 | Elongation factor, RNA polymerase II, 2 |
| NAP1L1 | 0.66 | Nucleosome assembly protein 1-like 1 |
| COL5A2 | 1.51 | Collagen, type V, alpha 2 |
| PDXK | 1.51 | Pyridoxal (pyridoxine, vitamin B6) kinase |
| GHR | 1.54 | Growth hormone receptor |
| NUCB1 | 1.55 | Nucleobindin 1 |
| CD81 | 1.56 | CD81 molecule |
| RBPMS2 | 1.59 | RNA binding protein with multiple splicing 2 |
| TIMP1 | 1.59 | TIMP metallopeptidase inhibitor 1 |
| ANXA5 | 1.59 | Annexin A5 |
| CAV1 | 1.60 | Caveolin 1, caveolae protein, 22 kDa |
| THY1 | 1.62 | Thy-1 cell surface antigen |
| PMP22 | 1.62 | Peripheral myelin protein 22 |
| COL5A1 | 1.63 | Collagen, type V, alpha 1 |
| FBLN1 | 1.63 | Fibulin 1 |
| FBN1 | 1.63 | Fibrillin 1 |
| CLDN5 | 1.66 | Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) |
| MSX1 | 1.66 | Msh homeobox 1 |
| COL1A2 | 1.69 | Collagen, type I, alpha 2 |
| PDGFRB | 1.7 | Platelet-derived growth factor receptor, beta polypeptide |
| FAP | 1.74 | Fibroblast activation protein, alpha |
| DCN | 1.74 | Decorin |
| MCAM | 1.79 | Melanoma cell adhesion molecule |
| COL6A3 | 1.8 | Collagen, type VI, alpha 3 |
| CILP | 1.99 | Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
| LUM | 2.03 | Lumican |
| COL1A1 | 2.05 | Collagen, type I, alpha 1 |
| FZD4 | 2.11 | Frizzled homolog 4 (Drosophila) |
| CTHRC1 | 2.17 | Collagen triple helix repeat containing 1 |
| HSPB6 | 2.17 | Heat shock protein, alpha-crystallin-related, B6 |
| RBP4 | 2.17 | Retinol binding protein 4, plasma |
| COL3A1 | 2.3 | Collagen, type III, alpha 1 |
| COL4A1 | 2.43 | Collagen, type IV, alpha 1 |
| ANGPTL2 | 2.7 | Angiopoietin-like 2 |
| CD36 | 3.07 | CD36 molecule (thrombospondin receptor) |
| FSTL1 | 3.15 | Follistatin-like 1 |
| PCOLCE2 | 3.64 | Procollagen C-endopeptidase enhancer 2 |
| LEP | 5.03 | Leptin |