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Effect of 11β-HSD1 deficiency on inflammatory monocytes (7/4hiLy6G−CD11b+) and neutrophils (7/4+Ly6G+CD11b+) in blood, BM, and spleen. DKO and ApoE-KO mice (4 wk old) were fed chow diet or WD for 14 wk, and then monocyte and neutrophil numbers in the blood (A), BM (B), and spleen (C) were quantified by flow cytometric analysis (n=5–21/group). *P < 0.05, **P < 0.01 for effects of genotype; †P < 0.05 for effects of diet.
