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. 2013 Apr;27(4):1519–1531. doi: 10.1096/fj.12-219105

Figure 6.

Figure 6.

Effect of 11β-HSD1 deficiency on circulating MCP-1 and mesenteric adipose tissue MCP-1 mRNA expression and mRNA expression of MCP-1, CCR2, CX3CR1, and VCAM-1 in the ascending aortas. ApoE-KO and DKO mice (4 wk old) were fed chow diet or WD for 14 wk. A, B) Serum MCP-1 level (A) and MCP-1 mRNA expression levels in MesAT (B) were elevated by WD in ApoE-KO control mice, but not in DKO mice. C, D) Furthermore, although aortic MCP-1 (C), and CCR2 (D) mRNA levels were elevated by WD, there was no difference by genotype. E) CX3CR1 mRNA transcript levels in the aorta were unaltered by genotype and diet. F) Aortic VCAM-1 mRNA levels were similar in ApoE-KO and DKO mice fed chow diet. However, while WD increased VCAM-1 mRNA in ApoE-KO mice, there was no change in DKO tissue (n=5–8/group). *P < 0.05, **P < 0.01 for effects of genotype; †P < 0.05, ††P < 0.01 for effects of diet.