Figure 8.

11β-HSD1 deletion in BM cells reduces atherosclerotic lesion size. Lethally irradiated ApoE-KO recipient mice were reconstituted with BM from ApoE-KO mice or DKO mice and fed WD for 12 wk. Formalin-fixed innominate arteries underwent OPT scanning. Analysis of lesion volumes (A) and lesion cross-sectional area (B) in the innominate arteries demonstrated that ApoE-KO recipient mice reconstituted with DKO BM cells exhibited significantly smaller lesions when compared to ApoE-KO mice reconstituted with ApoE-KO BM cells (n=5/group). *P < 0.05, **P < 0.01 vs. ApoE-KO mice reconstituted with ApoE-KO BM cells.