Table 2.
Effect of 11β-HSD1 deficiency on physiologic characteristics and metabolic parameters in ApoE-KO mice fed chow or WD for 14 wk
| Parameter | Chow |
WD |
||
|---|---|---|---|---|
| ApoE KO | DKO | ApoE KO | DKO | |
| Body weight (g) | 33.2 ± 1.2 (n=9) | 33.4.0 ± 0.8 (n=7) | 35.4 ± 0.5 (n=7) | 37.0 ± 1.2 (n=8)† |
| Food intake (g/wk) | ND | ND | 22.9 ± 2.0 (n=11) | 21.1 ± 0.8 (n=11) |
| Cholesterol (mM) | 7.6 ± 0.7 (n=14) | 12.8 ± 1.2 (n=14)* | 23.1 ± 1.9 (n=8)††† | 22.3 ± 1.9 (n=14)††† |
| Triglycerides (mM) | 0.92 ± 0.10 (n=14) | 0.96 ± 0.11 (n=14) | 2.07 ± 0.21 (n=11)††† | 1.40 ± 0.14 (n = 13)**,† |
| Mesenteric adipose tissue weight (mg) | 200.2 ± 35.8 (n=9) | 300.7 ± 50.4 (n=7) | 440.0 ± 64.6 (n=7)† | 446.4 ± 87.4 (n=8) |
| Liver weight ratio (mg/g BW) | 56.5 ± 3.4 (n=9) | 53.2 ± 2.4 (n=7) | 50.9 ± 2.9 (n=7) | 47.0 ± 3.2 (n=8) |
| Spleen weight ratio (mg/g BW) | 4.19 ± 0.34 (n=9) | 3.04 ± 0.16 (n=7)* | 4.03 ± 0.51 (n=7) | 5.60 ± 0.79 (n=8)†† |
| Thymus weight ratio (mg/g BW) | 1.42 ± 0.16 (n=9) | 1.30 ± 0.12 (n=7) | 1.32 ± 0.10 (n=7) | 1.18 ± 0.12 (n=8) |
Data are means ± se. BW, body weight; ND, not determined.
*
P < 0.05,
**
P < 0.01 for effect of genotype;
†
P < 0.05,
††
P < 0.01,
†††
P < 0.001 for effect of diet.