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Schematic illustration demonstrating signaling pathways involved in Tat-mediated microglial migration. Tat-mediated engagement of the VEGFR1 stimulated activation of MYLK, followed by inside-out activation of β1 integrin, and subsequent outside-in signaling of β1 integrin involving activation of the downstream kinases c-Src, Pyk2, and Cdc42-GTP, culminating ultimately in actin polymerization, leading to microglial migration.
