Table 2.
Test positivity in healthy subjects, by assay
| First author, year | Tested, N | Positive, n | % positive | 95% CI | Comment |
|---|---|---|---|---|---|
| PF4/heparin ELISA by Stago | |||||
| Arepally 1995 [20] | 77 | 1 | 1.3 | Mean OD492 0.19 ± 0.01 | |
| Bachelot-Loza 1998 [21] | 218 | 0 | 0 | Each subject: OD492<0.25 | |
| Newman 1998 [16] | 32 | 7 | 21.9 | Maximum OD490 ~1.1 | |
| Walenga 1999 [22] | 140 | 2 | 1.4 | OD492 not reported | |
| Woodhams 1999 [23] | 193 | 0 | 0 | OD492 0.01–0.38 | |
| Eichler 2002 [17] | 20 | 6 | 30.0 | Maximum OD492 ~0.75 | |
| Tazzari 2002 [24] | 30 | 0 | 0 | OD492 not reported | |
| de Larranaga 2002 [10] | 40 | 1 | 2.5 | OD492 not reported | |
| Lee 2003 [26] | 40 | 0 | 0 | OD492 not reported | |
| Overall | 790 | 17 | 2.2 | 1.1–3.2 | |
| PF4/PVS ELISA by GTI | |||||
| Eichler 2002 [17] | 20 | 1 | 5.0 | OD405 ~0.5 for single positive | |
| Untch 2002 [25] | 50 | 0 | 0 | Mean ± SEM OD410 ~0.28 ± 0.05 | |
| Tazzari 2002 [24] | 30 | 0 | 0 | OD405 not reported | |
| Overall | 100 | 1 | 1.0 | 0–3.0 | |
| PF4/heparin PGIA by DiaMed | |||||
| Eichler 2002 [17] | 20 | 0 | 0 | ||
| Tazzari 2002 [24] | 30 | 0 | 0 | ||
| Alberio 2003 [25] | 20 | 3 | 15.0 | Antibody titer of 1 for positives | |
| Overall | 70 | 3 | 4.3 | 0–9.0 |