. Author manuscript; available in PMC: 2013 Mar 23.

Published in final edited form as: J Am Chem Soc. 2004 Apr 28;126(16):5108–5112. doi: 10.1021/ja0394479

Table 2.

Several Parameters of Particles Properties and Binding Characteristics with Bupivacaine^a

parameter	microemulsion (ME-6)	macroemulsion (intralipid)
particle diameter (nm)	29 ± 2	430 ± 10
surface area of a particle (nm²)	2.697 × 10³	5.81 × 10⁵
particle density (particle/mL)	6.95 × 10¹⁴	1.08 × 10¹²
total interfacial area (m²/mL)	1.87	0.628
partition coefficient of drug	146.56	8.41
percentage volume of particle occupied by drug	40.27	2.049

To calculate number of droplets and interfacial area, per milliliter, it was assumed that particles are closely uniformly packed. Summary data is mean ± standard error of the mean. See Supporting Information for methods of calculation.