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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Arch Biochem Biophys. 2012 Sep 11;528(1):72–89. doi: 10.1016/j.abb.2012.09.002

Figure 3.

Figure 3

Evolutionary origins of the structures of NADPH-cytochrome P450 reductase (CYPOR) and nNOS reductase domain (nNOS-red) as shown by overlays of the ribbon structures of D. vulgaris flavodoxin (Fld) and spinach ferredoxin-NADP-oxidoreductase (FNR). A, A model of a putative Fld-FNR complex [31]; B, CYPOR structure [36]. The FMN domain, FAD domain, and connecting domain (CD) are marked; C, structure of the nNOS reductase domain (nNOSred) [42] containing regulatory elements, AR, CT and BF shown in red; D, overlay of the structures of Fld, FNR and CYPOR; E, overlay of CYPOR and nNOSred.