Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Arch Biochem Biophys. 2012 Sep 11;528(1):72–89. doi: 10.1016/j.abb.2012.09.002

Figure 4.

Figure 4

Topology of CYPOR and P450 and the formation of their complex on the ER membrane. CYPOR is in a dynamic equilibrium between the closed and open forms. In the closed form, FMN accepts electrons from FAD and, in its open form, donates electrons to P450. The encounter complex consists of multiple protein orientations leading to the single orientation forming the specific complex. CYPOR is shown in a closed conformation, when the nucleotide (NADPH or NADP+) is bound and opens up in the presence of electron acceptors, e.g., cyt c or P450s (see section 2.1 for detailed discussion).