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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Arch Biochem Biophys. 2012 Sep 11;528(1):72–89. doi: 10.1016/j.abb.2012.09.002

Figure 7.

Figure 7

Electron Transfer Path in CYPOR (A) and NOS (B). The P450 ET system catalyzes the monoxygenation of substrate (RH) (red) (A), while NOS isoforms catalyze the formation of NO from l-Arg (blue) (B), via two- monooxygenation reactions with NG-hydroxy-l-Arginine (NG-hydroxy-l-Arg) as a stable intermediate. In nNOS and eNOS, all three electron-transfer steps are accelerated by CaM binding. The dotted lines from FMN to ferricyanide indicate that, although thermodynamically possible, ET between fully reduced FMN and ferricyanide has not studied in details.