Table 3.
Most significant canonical pathways determined by Ingenuity Pathway Analysis and represented in the assembled gilthead sea bream transcriptome
| Canonical pathway | E-value | Molecules | Canonical pathway | E-value | Molecules |
|---|---|---|---|---|---|
| Regulation of eIF4 and p70S6K Signaling |
1.58E-23 |
130 |
Erythropoietin Signaling |
8.32E-08 |
56 |
| Purine Metabolism |
7.94E-23 |
219 |
Ubiquinone Biosynthesis |
9.12E-08 |
58 |
| EIF2 Signaling |
3.98E-21 |
156 |
AMPK Signaling |
9.33E-08 |
100 |
| Protein Ubiquitination Pathway |
7.94E-20 |
207 |
Induction of Apoptosis by HIV1 |
1.05E-07 |
51 |
| Glucocorticoid Receptor Signaling |
2.51E-17 |
203 |
IL-2 Signaling |
1,17E-07 |
46 |
| mTOR Signaling |
2.51E-16 |
148 |
CD40 Signaling |
1,20E-07 |
53 |
| Molecular Mechanisms of Cancer |
6.31E-16 |
250 |
Role of NFAT in Cardiac Hypertrophy |
1,29E-07 |
131 |
| Mitochondrial Dysfunction |
1.00E-15 |
114 |
HGF Signaling |
1,48E-07 |
77 |
| Integrin Signaling |
6.31E-14 |
155 |
FLT3 Signaling in Hematopoietics |
1,55E-07 |
59 |
| Inositol Phosphate Metabolism |
2.51E-13 |
122 |
Progenitor Cells |
|
|
| Thrombin Signaling |
1.58E-12 |
147 |
Fcγ Receptor-mediated Phagocytosis in |
1,58E-07 |
73 |
| Signaling by Rho Family GTPases |
1.58E-12 |
174 |
Macrophages and Monocytes |
|
|
| Estrogen Receptor Signaling |
3.16E-12 |
104 |
Sphingosine-1-phosphate Signaling |
1,66E-07 |
86 |
| CXCR4 Signaling |
5.01E-12 |
121 |
FAK Signaling |
1,66E-07 |
69 |
| Oxidative Phosphorylation |
6.31E-12 |
115 |
Paxillin Signaling |
2,09E-07 |
78 |
| Acute Phase Response Signaling |
7.94E-12 |
130 |
Small Cell Lung Cancer Signaling |
2,40E-07 |
58 |
| Breast Cancer Regulation by Stathmin1 |
1.26E-11 |
147 |
T Cell Receptor Signaling |
3,31E-07 |
75 |
| Type II Diabetes Mellitus Signaling |
3.98E-11 |
94 |
B Cell Receptor Signaling |
3,31E-07 |
105 |
| Huntington’s Disease Signaling |
5.01E-11 |
161 |
Production of Nitric Oxide and Reactive |
3,72E-07 |
126 |
| Pyrimidine Metabolism |
7.94E-11 |
111 |
Oxygen Species in Macrophages |
|
|
| NGF Signaling |
7.94E-11 |
86 |
LPS-stimulated MAPK Signaling |
3,89E-07 |
59 |
| PI3K/AKT Signaling |
1.10E-10 |
96 |
Insulin Receptor Signaling |
3,98E-07 |
96 |
| RAR Activation |
1.38E-10 |
130 |
Cyclins and Cell Cycle Regulation |
3,98E-07 |
63 |
| Androgen Signaling |
1.62E-10 |
91 |
PI3K Signaling in B Lymphocytes |
4,57E-07 |
99 |
| Tight Junction Signaling |
1.86E-10 |
120 |
IGF-1 Signaling |
4,68E-07 |
76 |
| Chronic Myeloid Leukemia Signaling |
4.68E-10 |
78 |
p53 Signaling |
5,25E-07 |
72 |
| NRF2-mediated Oxidative Stress Response |
8.51E-10 |
134 |
VEGF Signaling |
5,62E-07 |
68 |
| PPARα/RXRα Activation |
1.12E-09 |
128 |
Prostate Cancer Signaling |
6,03E-07 |
64 |
| Actin Cytoskeleton Signaling |
1.78E-09 |
154 |
Nicotinate and Nicotinamide Metabolism |
6,46E-07 |
77 |
| Ceramide Signaling |
2.00E-09 |
66 |
Relaxin Signaling |
6,46E-07 |
98 |
| Role of Tissue Factor in Cancer |
2.29E-09 |
87 |
Glioma Signaling |
7,24E-07 |
73 |
| Hereditary Breast Cancer Signaling |
3.31E-09 |
92 |
Pentose Phosphate Pathway |
7,94E-07 |
29 |
| ERK/MAPK Signaling |
3.72E-09 |
135 |
Pancreatic Adenocarcinoma Signaling |
8,13E-07 |
80 |
| NF-κB Activation by Viruses |
4.57E-09 |
62 |
Mitotic Roles of Polo-Like Kinase |
8,51E-07 |
51 |
| Apoptosis Signaling |
4.68E-09 |
73 |
Acute Myeloid Leukemia Signaling |
9,33E-07 |
61 |
| Gα12/13 Signaling |
4.90E-09 |
93 |
PDGF Signaling |
9,33E-07 |
57 |
| Cardiac Hypertrophy Signaling |
5.13E-09 |
159 |
CNTF Signaling |
1,05E-06 |
44 |
| Rac Signaling |
5.37E-09 |
83 |
Endometrial Cancer Signaling |
1,05E-06 |
44 |
| Germ Cell-Sertoli Cell Junction Signaling |
6.17E-09 |
118 |
Thrombopoietin Signaling |
1,17E-06 |
46 |
| ILK Signaling |
6.76E-09 |
135 |
Melanocyte Development and Pigmentation |
1,29E-06 |
66 |
| Renin-Angiotensin Signaling |
7.94E-09 |
86 |
Signaling |
|
|
| Protein Kinase A Signaling |
8.51E-09 |
212 |
Prolactin Signaling |
1,45E-06 |
58 |
| Aldosterone Signaling in Epithelial Cells |
8.91E-09 |
117 |
Colorectal Cancer Metastasis Signaling |
1,58E-06 |
161 |
| RhoGDI Signaling |
9.12E-09 |
129 |
RANK Signaling in Osteoclasts |
1,82E-06 |
67 |
| p70S6K Signaling |
1.00E-08 |
95 |
IL-17A Signaling in Airway Cells |
2,19E-06 |
51 |
| IL-8 Signaling |
1.02E-08 |
127 |
Aminoacyl-tRNA Biosynthesis |
2,40E-06 |
30 |
| IL-15 Signaling |
1.15E-08 |
53 |
G Beta Gamma Signaling |
2,51E-06 |
68 |
| fMLP Signaling in Neutrophils |
1.23E-08 |
85 |
Telomerase Signaling |
2,69E-06 |
75 |
| Phospholipase C Signaling |
1.78E-08 |
163 |
IL-6 Signaling |
3,16E-06 |
71 |
| PAK Signaling |
1.91E-08 |
72 |
Role of BRCA1 in DNA Damage Response |
3,24E-06 |
46 |
| P2Y Purigenic Receptor Signaling Pathway |
2.24E-08 |
93 |
Death Receptor Signaling |
3,39E-06 |
48 |
| HMGB1 Signaling |
3.02E-08 |
75 |
IL-3 Signaling |
3,39E-06 |
56 |
| Leukocyte Extravasation Signaling |
3.16E-08 |
137 |
Starch and Sucrose Metabolism |
3,47E-06 |
54 |
| RhoA Signaling |
3.89E-08 |
86 |
GM-CSF Signaling |
3,47E-06 |
50 |
| PTEN Signaling |
4.07E-08 |
84 |
Angiopoietin Signaling |
3,47E-06 |
52 |
| Virus Entry via Endocytic Pathways |
4.57E-08 |
72 |
Non-Small Cell Lung Cancer Signaling |
3,47E-06 |
52 |
| Growth Hormone Signaling |
5.13E-08 |
57 |
Role of NFAT in Regulation of the Immune |
3,72E-06 |
120 |
| JAK/Stat Signaling |
6.31E-08 |
52 |
Response |
|
|
| Lymphotoxin β Receptor Signaling | 7.08E-08 | 47 | Neuregulin Signaling | 3,72E-06 | 67 |